Lipoprotein metabolism in experimental nephrosis
نویسندگان
چکیده
منابع مشابه
Lipoprotein metabolism in experimental nephrosis.
In experimental nephrosis, a decrease in plasma albumin resulting from proteinuria causes a decreased in the plasma oncotic pressure. The existence of an osmoreceptor, which responds to the low oncotic pressure and produces a factor(s) that signals the liver to increase the secretion of plasma proteins, is postulated. The hyperlipidemia characteristic of the nephrotic syndrome results primarily...
متن کاملSerum lipid and lipoprotein alterations in nephrosis.
When nephrosis was recognized as a clinical entity, an increased concentration of serum cholesterol was observed to be a consistent feature of the syndrome (1). Later it was found that phospholipid and triglyceride also are increased in nephrosis (2-5). The increase in serum lipids in nephrosis is usually greatest in the cases with the lowest levels of serum albumin. It has not been established...
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In 1923, not many years after Epstein's (1) original characterization of lipoid nephrosis, Salvesen and Linder (2) first observed a lowering of the serum calcium concentration which paralleled the decrease in serum protein level in patients with this disease.' In addition, two other features indicating a disturbance of calcium metabolism in nephrosis have been described. Boyd, Courtney, and Mac...
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The effect of the sulfur-substituted fatty acid analogue 1,10 bis(carboxymethylthio)decane, also known as 3-thiadicarboxylic acid, on puromycin aminonucleoside-induced nephrotic hyperlipidemia was studied in rats. Treatment with 3-thiadicarboxylic acid (250 mg/kg) for 5 days reduced plasma levels of triglycerides from 5.8 to 2.7 mmol/L and cholesterol from 11.0 to 7.7 mmol/L. This was accounted...
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The effects of experimental nephrosis in rats, produced by puromycin aminonucleoside, include an elevation of plasma levels of all lipoprotein density classes and the appearance of high density lipoprotein (HDL) rich in apoprotein (apo) A-I and deficient in apo A-IV and apo E. The hyperlipoproteinemia is associated with an increase in hepatic synthesis of lipoproteins. The possible role of decr...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1984
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)34440-0